Project overview
Our lab is using state-of-the-art mass spectrometry to uncover how tryptophan metabolism regulates blood pressure during sepsis. This pathway, driven by the enzyme IDO1, produces highly reactive oxygen species and unique tryptophan-derived compounds that profoundly affect vascular function. While we’ve defined this mechanism in animal models, the exciting challenge now is to confirm its activity in humans for the very first time. This project offers the opportunity to make a breakthrough discovery, with training in redox biology, and analytical biochemistry.