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Biography

Dr Xin (Tracy) Liu completed her PhD in the Lipid Cell Biology Laboratory at the Centenary Institute, University of Sydney, under the supervision of A/Prof Jacob Qi. She continued her research at the Centenary Institute as a Research Officer following her doctoral studies.

Tracy’s research focuses on the role of sphingolipids—particularly sphingosine kinases—in mitochondrial biology and liver disease. Her work spans human liver lipidomics, mechanistic studies in animal models, and the development of novel therapeutic strategies.

Publications

Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y§. (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine. 22: 43.

Liu, X. T., Chung, L. H., Liu, D., Chen, J., Huang, Y., Teo, J. D., Han, X. D., Zhao, Y., Guan, F. H. X., Tran, C., Lee, J. Y., Couttas, T. A., Liu, K., McCaughan, G. W., Gorrell, M. D., Don, A. S., Zhang, S., & Qi, Y. (2022). Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis, 11(1), 67.

Trapika, I. G. M. G. S. C.*, Liu, X. T.*, Chung, L. H., Lai, F., Xie, C., Zhao, Y., Cui, S., Chen, J., Tran, C., Wang, Q., Zhang, S., Don, A. S., Li, G. Q., Hanrahan, J. R., Qi, Y. (2021). Ceramide Regulates Anti- Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers. Frontiers in oncology, 11, 738078. *, co-first author.

Jiang YC, Lai K, Muirhead RP, Chung LH, Huang Y, James E, Liu XT, Wu J, Atkinson FS, Yan S, Fogelholm M, Raben A, Don AS, Sun J, Brand-Miller JC, Qi Y. (2024). Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses to successful weight loss: a PREVIEW sub-study. The American Journal of Clinical Nutrition. 120(4): 864-878.

Qi, Y., Wang, W., Song, Z., Aji, G., Liu, X. T., & Xia, P. (2021). Role of Sphingosine Kinase in Type 2 Diabetes Mellitus. Frontiers in endocrinology, 11, 627076.

Chung, L. H., Liu, D., Liu, X. T., & Qi, Y. (2021). Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer. International journal of molecular sciences, 22(24), 13184.