Dr Lining Ju completed his PhD in biomechanics and biomedical engineering and received the SigmaXi best thesis award at the Georgia Institute of Technology and Emory University, supervised by Regents’ Professor Cheng Zhu – a world leader in biomechanics and mechanobiology.
After moving to Australia, his research focus shifted to thrombotic disease. He has developed a state-of-the-art nanotool (Biomembrane force probe ‘BFP’) to examine single-molecule force sensing principles that are significantly implicated in thrombotic diseases and anti-platelet therapeutics. He is currently collaborating with Prof Dayong Jin at the University of Technology, Sydney to develop a new super-resolution imaging platform for visualising the nanoscale inner workings of human cardiovascular cell systems.
The ultimate goal of his research is to develop new ‘mechanomedicines’ with ultrasensitive biomechanical and imaging approaches to detect and target disease markers faster, cheaper and more effectively than current technology allows.
Prizes and awards
2018 CSANZ Bayer Young Investigator Research Grant
2018 Heart Research Institute Best Publication Award
2015 Heart Research Institute Best Presentation Award
2013 ISTH Young Investigator Award
2012 American Society of Hematology Achievement Award
2018 Australian Research Council (ARC) Discovery Early Career Researcher Award (DECRA)
2017 Australia Heart Foundation Postdoctoral Fellowship
2015 University of Sydney Early Career Kickstart Grant
2014 THANZ Society Travel Award
Ju, L., Chen, Y., Li, K., Yuan, Z., Liu, B., Jackson, S.P. and Zhu, C. (2017) Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species. Scientific Reports 7, 14185
Samson, A.L., Ju, L., Kim, H.A., Zhang S.R., Lee, J.A.A., Sturgeon, S.A., Sobey, C.G., Jackson, S.P. and Schoenwaelder, S.M. (2015). MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents. Scientific Reports 5,16171.
Ju, L., and Zhu, C. (2014). Biomechanical role of von Willebrand factor and glycoprotein Iba interaction in platelet thrombus formation. International Review of Thrombosis 9, 30–38.
Ju, L., Dong, J.-F., Cruz, M.A., and Zhu, C. (2013). The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Iba. Journal of Biological Chemistry 288, 32289–32301.
Cheng Zhu (Single-molecule biomechanics; Georgia Tech)
Philip Hogg (Biochemistry; University of Sydney)
Dayong Jin (Super resolution imaging; University of Technology, Sydney)